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Changes in Protein Expression of Oral Cancer Cells Continuosly Exposed to Porphyromonas gingivalis

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À§½Å¿í ( Wi Sin-Wook ) - ºÎ»ê´ëÇб³ Ä¡ÀÇÇÐÀü¹®´ëÇпø ±¸°­º´¸®Çб³½Ç
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±è´ÙÁ¤ ( Kim Da-Jeong ) - ºÎ»ê´ëÇб³ Ä¡ÀÇÇÐÀü¹®´ëÇпø ±¸°­º´¸®Çб³½Ç
ÀÌÁöÇý ( Lee Ji-Hye ) - ºÎ»ê´ëÇб³ Ä¡ÀÇÇÐÀü¹®´ëÇпø ±¸°æº´¸®Çб³½Ç
¹ÚºÀ¼ö ( Park Bong-Soo ) - ºÎ»ê´ëÇб³ Ä¡ÀÇÇÐÀü¹®´ëÇпø ±¸°­ÇغÎÇб³½Ç
¹ÚÇý·Ã ( Park Hae-Ryoun ) - ºÎ»ê´ëÇб³ Ä¡ÀÇÇÐÀü¹®´ëÇпø ±¸°­º´¸®Çб³½Ç

Abstract


Porphyromonas gingivalis is a gram-negative bacteria of rod shape, and grown in an anerobic condition. It colonizes in subgingival crevice and is known as a major pathogen causing chronic periodontitis. It possesses an invasive property and replicative potential within various cell types, presumably playing an important role in modulating biological behaviors of oral cancer. However, the pathophysiology of P. gingivalis in the malignant transformation of oral cancer has not been fully understood. In this study, we aimed to investigate molecular changes of oral squamous cell carcinoma cells induced by repetitive P. gingivalis infection that clinically resembles chronic periodontitis.

Å°¿öµå

Porphyromonas gingivalis; Oral Cancer; Periodontitis; L-plastin; S1009A

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